A little cooperation: A cooperative copper- and palladium-catalyzed highly regio- and chemoselective three-component coupling of benzynes, allylic epoxides, and terminal alkynes provides an efficient atom-economical route to ortho-disubstituted arenes. The resulting product undergoes a gold-catalyzed cyclization reaction (see scheme; dba=dibenzylideneacetone, dppp=1,3-bis(diphenylphosphanyl)propane).
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Jeganmohan et al. (2008) studied this question.
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