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January 1, 2001Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human ScienceOpen Access

Evaluation of Disuse Atrophy of Rat Skeletal Muscle Based on Muscle Energy Metabolism Assessed by 31P-MRS.

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Population

24 male 14-week old Sprague-Dawley rats

Comparison

Hind-limb suspension for 3, 7, or 14 days vs Control group (no suspension)

Design

Preclinical

Follow-up

Up to 14 days

Authors

NYNaoyuki YoshidaCreative Technology (Singapore)TITakaaki IkataHealth FirstKSKoichi SairyoCentre de Recherche en Sciences et Technologies de l'Information et de la Communication

Discussion

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Overview

Suggests separate countermeasures for mass versus function loss; hypothesis-generating in rat model, requires human validation.

Structured PICO

P
Population
24 male 14-week old Sprague-Dawley rats
I
Intervention
Hind-limb suspension for 3, 7, or 14 days
C
Comparator
Control group (no suspension)
O
Outcome
Muscle mass (wet weight), maximum tension, and oxidative capacity (assessed by 31P-MRS)surrogate

In a rat model of disuse atrophy, muscle mass and muscle function (oxidative capacity and maximum tension) do not deteriorate simultaneously, suggesting independent countermeasures are needed.

Limitations

  • Force time rate was not normalized by the muscle cross sectional area, so evaluation of the muscle oxidative capacity might not be strictly qualitative.

Cite This Study

Yoshida et al. (2001) studied this question.

synapsesocial.com/papers/6a6f233d6ceb2bbd16df9dbahttps://doi.org/10.2114/jpa.20.247
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