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December 1, 1992AJP Heart and Circulatory Physiology

Heart size and maximal cardiac output are limited by the pericardium

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Authors

HHH. Kirk HammondVA San Diego Healthcare SystemFWF. C. WhiteSeaWorld EntertainmentVBValmik BhargavaUniversidade Federal do Rio de Janeiro

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Implication

Pericardiectomy boosts maximal cardiac output and VO2 in pigs; leaves open any role in human exercise limits or HFpEF therapies.

Key Points

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Cite This Study

Hammond et al. (1992) studied this question.

synapsesocial.com/papers/6a6f233d6ceb2bbd16df9dbbhttps://doi.org/10.1152/ajpheart.1992.263.6.h1675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of pericardiotomy on exercise-induced pulmonary hypertension in the horse2006 · 2 citations
  2. 2The effect of pericardium on the end-systolic pressure-segment length relationship in canine left ventricle in acute volume overload.1983 · 19 citations
  3. 3The pericardium exerts constraint on the right ventricle during cardiac surgery1990 · 14 citations
  4. 4The effect of pericardium on the diastolic properties of the heart -Experimental studies on volume load and on acute ischemia in open chest dogs-.1982 · 8 citations
  5. 5Left ventricular pressure-volume relations shift to the left after long-term loss of pericardial restraint.1983 · 15 citations