Key result
Meeting the HFA-ESC advanced heart failure definition predicted higher 1-year all-cause mortality or HF hospitalization (69.3% vs 41.8%; adjusted HR 1.98, 95% CI 1.57-2.50, P<0.001).
Why the study?
The Heart Failure Association of the European Society of Cardiology (HFA-ESC) proposed a definition of advanced HF that had not yet been validated.
Does meeting the 2018 HFA-ESC definition of advanced heart failure predict all-cause mortality or HF hospitalization in high-risk HF patients?
Population
1149 high-risk HF patients with at least one I NEED HELP marker
Comparison
Meeting HFA-ESC advanced HF definition vs not meeting the definition
Design
Multicentre cohort study
Follow-up
1-year
Authors
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Reinforces HFA-ESC definition utility for risk stratification; extends validation but leaves open impact on management.
Cohort (n=1,149)
Yes
Does meeting the 2018 HFA-ESC definition of advanced heart failure predict all-cause mortality or HF hospitalization in high-risk HF patients?
Hazard Ratio: 2.23 (95% CI 1.82–2.74)
Absolute Event Rate: 69.3% vs 41.8%
p-value: p=<0.001
The 2018 HFA-ESC definition of advanced heart failure is a strong independent predictor of mortality and hospitalization in high-risk heart failure patients.
Pagnesi et al. (2022) conducted a cohort in High-risk heart failure (n=1,149). HFA-ESC advanced HF definition vs. Not meeting the HFA-ESC advanced HF definition was evaluated on Composite of all-cause mortality or first HF hospitalization (HR 2.23, 95% CI 1.82-2.74, p=<0.001). Meeting the HFA-ESC advanced heart failure definition predicted higher 1-year all-cause mortality or HF hospitalization (69.3% vs 41.8%; adjusted HR 1.98, 95% CI 1.57-2.50, P<0.001).
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