October 1, 1991Journal of Biological ChemistryOpen Access

Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes.

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Population

3T3-L1 adipocytes and HepG2 cells

Design

Preclinical

Authors

LPL. PreviatoUniversity of Padua CPCatherine L. ParrottNational Institutes of Health SSSilvia Santamarina-FojoNational Institutes of Health

Discussion

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Implication

Identifies a key positive regulatory motif for LPL; leaves open its in vivo role and any therapeutic relevance.

Structured PICO

Population

3T3-L1 adipocytes and HepG2 cells

Intervention

Transfection with plasmids containing deletion mutants of the 5'-LPL promoter region and the luciferase reporter gene

Outcome

Transcriptional activity (luciferase expression)surrogate

The expression of lipoprotein lipase in adipocytes is modulated by multiple positive and negative regulatory elements within the 5'-flanking region of the LPL gene, including a proximal octamer binding sequence.

Cite This Study

Previato et al. (1991) studied this question.

synapsesocial.com/papers/6a6f23ba22b3175134db4182 https://doi.org/10.1016/s0021-9258(18)55156-5

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Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider