Why the study?
Does bevantolol improve regional myocardial blood flow and contractile function in ischemic myocardium in open-chest dogs?
Population
Open-chest dogs with severe flow-limiting stenosis of the left circumflex coronary artery
Comparison
Bevantolol administered 30 min after production… vs Saline
Design
Preclinical
Authors
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Favorable redistribution in canine ischemia; leaves open translation to human coronary disease.
Does bevantolol improve regional myocardial blood flow and contractile function in ischemic myocardium in open-chest dogs?
Bevantolol produces a favorable redistribution of blood flow to the ischemic subendocardium, improving contractile function in a canine model of coronary stenosis.
Gross et al. (1979) studied this question.
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