Key result
Rivaroxaban effectively prevents and treats thromboembolic events across indications without routine coagulation monitoring.
Why the study?
Does rivaroxaban effectively prevent and treat thromboembolic events across various clinical indications compared to traditional anticoagulants or placebo?
Does rivaroxaban effectively prevent and treat thromboembolic events across various clinical indications compared to traditional anticoagulants or placebo?
Rivaroxaban provides a convenient, effective, and safe oral alternative to traditional anticoagulants for a broad spectrum of thromboembolic disorders, avoiding the need for routine coagulation monitoring.
Supports rivaroxaban as a convenient alternative across thromboembolic indications; leaves open need for updated real-world comparisons with newer agents.
Arterial and venous thromboembolic diseases are a clinical and economic burden worldwide. In addition to traditional agents such as vitamin K antagonists and heparins, newer oral agents - such as the factor Xa inhibitors rivaroxaban, apixaban, and edoxaban, and the direct thrombin inhibitor dabigatran - have been shown to be effective across several indications. Rivaroxaban has been shown to have predictable pharmacokinetic and pharmacodynamic properties, including a rapid onset of action. In addition, there is no requirement for routine coagulation monitoring; and no dose adjustment is necessary for age alone, sex, or body weight. Rivaroxaban has successfully met primary efficacy and safety endpoints in large, randomized phase III trials across several indications, including: prevention of venous thromboembolism in orthopedic patients undergoing elective hip or knee replacement surgery; treatment of deep vein thrombosis and secondary prevention of deep vein thrombosis and pulmonary embolism; stroke prevention in patients with atrial fibrillation; and secondary prevention of acute coronary syndrome. Rivaroxaban and the other newer oral anticoagulants are likely to improve outcomes in the prevention and treatment of thromboembolic events, and will offer patients and physicians alternative treatment options.
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Alexander G.G. Turpie (2012) conducted a review in Arterial and venous thromboembolic diseases (n=75,000). Rivaroxaban vs. Traditional anticoagulants (enoxaparin, vitamin K antagonists) or placebo was evaluated. Rivaroxaban is an effective and safe oral factor Xa inhibitor that improves outcomes across multiple indications for the prevention and treatment of thromboembolic events without requiring routine coagulation monitoring.
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