Key result
Steroids measured 15 minutes post-ACTH stimulation achieved the highest discriminatory performance between aldosterone-producing adenoma and bilateral primary aldosteronism (AUC 0.957).
Why the study?
Dynamic manipulation of the hypothalamic-pituitary-adrenal axis could assist primary aldosteronism subtyping, but a direct comparison of dynamic tests is lacking.
Does dynamic HPA testing with ACTH stimulation maximize the accuracy of peripheral steroid profiling in differentiating primary aldosteronism subtypes?
Population
80 patients with primary aldosteronism (40 with APA and 40 with BPA)
Comparison
APA vs BPA during dynamic HPA testing
Design
Prospective diagnostic testing study
Authors
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May aid noninvasive PA subtyping; leaves open prospective validation before clinical adoption.
Observational (n=80)
Does dynamic HPA testing with ACTH stimulation maximize the accuracy of peripheral steroid profiling in differentiating primary aldosteronism subtypes?
Effect estimate: AUC 0.957
Tezuka et al. (2021) conducted an observational in Primary aldosteronism (n=80). Aldosterone-producing adenoma (APA) vs. Bilateral primary aldosteronism (BPA) was evaluated on Discriminatory performance between PA subtypes using steroids measured 15 minutes post-ACTH stimulation (AUC 0.957). Steroids measured 15 minutes post-ACTH stimulation achieved the highest discriminatory performance between aldosterone-producing adenoma and bilateral primary aldosteronism (AUC 0.957).
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