Key result
Aldosterone-producing adenomas exhibited 2.88-fold higher transcript levels of MC2R and 1.80-fold higher levels of AGTR1 compared to adjacent normal adrenal tissue.
Why the study?
Little is known regarding possible variations in response to hormonal stimuli between aldosterone-producing adenomas with different aldosterone-driver mutations.
Comparison
APAs with KCNJ5, ATP1A1, CACNA1D, or ATP2B3 mutations vs normal adjacent adrenal tissue
Design
Observational study
Authors
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May implicate MC2R and AGTR1 in APA pathogenesis; leaves open therapeutic targeting pending prospective studies.
Observational (n=47)
No
Effect estimate: 2.88-fold
Absolute Event Rate: 2.88% vs 0.99%
p-value: p=<0.001
Lim et al. (2021) conducted an observational in Primary aldosteronism (Aldosterone-producing adenomas) (n=47). Aldosterone-producing adenomas vs. Adjacent normal adrenal tissue was evaluated on MC2R transcript expression (2.88-fold, p=<0.001). Aldosterone-producing adenomas exhibited 2.88-fold higher transcript levels of MC2R and 1.80-fold higher levels of AGTR1 compared to adjacent normal adrenal tissue.
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