Prophylactic anticoagulation with enoxaparin: Is the subcutaneous route appropriate in the critically ill?*

29 patients with normal renal function, comprising 16 critically ill ICU patients (mean age 61.1, 7 males) and 13 noncritically ill medical patients (mean age 61.7, 7 males). Excluded: impaired renal function, receiving hemofiltration, or requiring therapeutic anticoagulation.

Enoxaparin 40 mg subcutaneous once daily for up to 5 days in critically ill patients

Enoxaparin 40 mg subcutaneous once daily for up to 5 days in noncritically ill medical patients

Anti-Xa activities at 0, 1, 3, 6, and 12 hrs after a single daily subcutaneous dose of 40 mg enoxaparin on day 1 and at 3 hrs on days 2-5surrogate