Key result
High systolic home blood pressure variability was associated with a greater increase in rate-pressure product during cold exposure compared to low variability (1,850 vs 930 bpm × mm Hg; P<0.01).
Why the study?
Exaggerated sympathetic cardiovascular reactivity to stress increases cardiovascular disease risk, but feasible methods to identify these individuals in routine care are needed.
Does high home blood pressure variability associate with an exaggerated cardiac workload response to cold stress in middle-aged men?
Observational (n=75)
Does high home blood pressure variability associate with an exaggerated cardiac workload response to cold stress in middle-aged men?
Absolute Event Rate: 1850% vs 930%
p-value: p=<0.01
High home systolic blood pressure variability is associated with an exaggerated cardiac workload and blood pressure response to cold stress, suggesting augmented sympathetic vascular reactivity.
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Hypothesis-generating for BP variability as cold stress marker; prospective studies needed before clinical adoption.
Hintsala et al. (2019) conducted an observational in Hypertension / Cardiovascular reactivity (n=75). High systolic home blood pressure variability vs. Low systolic home blood pressure variability was evaluated on Rate-pressure product (RPP) increase during whole-body cold exposure (p=<0.01). High systolic home blood pressure variability was associated with a greater increase in rate-pressure product during cold exposure compared to low variability (1,850 vs 930 bpm × mm Hg; P<0.01).
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