Linkage of gut microbiome with cognition in hepatic encephalopathy
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Implication
Randomized trial links gut microbiome alterations to cognition and inflammation in hepatic encephalopathy, suggesting significant implications for treatment.
Key Points
- This research aimed to investigate the relationship between gut microbiome changes and cognitive function in patients with hepatic encephalopathy.
- Multitag pyrosequencing performed on stool samples from patients with cirrhosis and controls
- Correlation-network analysis of cognitive scores and inflammatory markers
- Assessment of stool microbiome changes before and after lactulose withdrawal for a select group
- Cirrhotics with HE showed increased Enterobacteriaceae, Alcaligeneceae, and Fusobacteriaceae and decreased Ruminococcaceae compared to controls.
- Positive correlations were found between cognitive impairment and Alcaligeneceae and Porphyromonadaceae in cirrhotics.
- Robust network correlations (all P < 1E-5) exist in HE between microbiome composition, cognition, and inflammation markers (IL-2, IL-13, IL-23).
Cite This Study
Bajaj et al. (2011) studied this question.