Key result
Patient age, rather than CYP2D6 genotype, was the only significant predictor of maximal heart rate at exertion (β = -0.6; p < 0.001) in patients with acute coronary syndrome treated with bisoprolol.
Why the study?
The study evaluated the influence of CYP2D6*3 and CYP2D6*4 genetic variants and other factors on the effects of bisoprolol in patients with acute coronary syndrome.
Do CYP2D6 genetic variants influence maximal heart rate at exertion in patients with acute coronary syndrome treated with bisoprolol?
Observational (n=97)
Do CYP2D6 genetic variants influence maximal heart rate at exertion in patients with acute coronary syndrome treated with bisoprolol?
Effect estimate: β = -0.6
p-value: p=<0.001
Age, rather than CYP2D6 genotype, is the primary predictor of maximal heart rate during exertion in acute coronary syndrome patients treated with bisoprolol.
Age should guide exertional heart rate expectations on bisoprolol in ACS; leaves open whether CYP2D6 genotyping adds value.
We have analyzed the influence of genetic variants CYP2D6*3 (2549delA) and CYP2D6*4 (1846G>A), as well as other factors on the effects of bisoprolol in patients with acute coronary syndrome. The study included 97 patients with acute coronary syndrome. The mean age was 63 ± 10 years; 60 men and 37 women. We have found association between carriage of CYP2D6*4 (1846G>A) and maximal heart rate at exertion (R 0.21; р < 0.05). When the correction for potential confounders was made, age was the only significant predictor of maximal heart rate (β = –0.6; SE = 0.07; p < 0.001). At the same time, it was found that CYP2D6*4 was associated with more advanced age of the patients (r = 0.2; p < 0.05).
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Shumkov et al. (2021) conducted an observational in acute coronary syndrome (n=97). CYP2D6*3 and CYP2D6*4 genotypes and patient age was evaluated on maximal heart rate at exertion (β = -0.6, p=<0.001). Patient age, rather than CYP2D6 genotype, was the only significant predictor of maximal heart rate at exertion (β = -0.6; p < 0.001) in patients with acute coronary syndrome treated with bisoprolol.
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