Key result
In 71 patients with acute coronary syndrome, higher total daily doses and cigarette smoking were the only 2 covariates found to increase the total clearance of bisoprolol.
Why the study?
Questions regarding pharmacokinetic variability of bisoprolol remain unanswered, and no published population pharmacokinetic analyses exist in routinely treated patients with acute coronary syndrome.
What covariates influence the population pharmacokinetics and clearance of bisoprolol in patients with acute coronary syndrome?
Population
71 Serbian patients with ACS
Comparison
Bisoprolol once or twice daily at total daily doses of 0.625-7.5 mg
Design
Population pharmacokinetic analysis
Authors
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Smoking and higher doses may increase bisoprolol clearance in ACS; hypothesis-generating for dosing adjustments pending validation.
Observational (n=71)
What covariates influence the population pharmacokinetics and clearance of bisoprolol in patients with acute coronary syndrome?
Higher total daily doses and smoking may increase the total clearance of bisoprolol in patients with acute coronary syndrome, potentially due to autoinduction and CYP3A4 induction.
Momčilović et al. (2018) conducted an observational in Acute Coronary Syndrome (n=71). Bisoprolol was evaluated on Pharmacokinetic variability (clearance of bisoprolol). In 71 patients with acute coronary syndrome, higher total daily doses and cigarette smoking were the only 2 covariates found to increase the total clearance of bisoprolol.
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