Why the study?
Does age affect the venodilatory response to isoproterenol and PGE1 in healthy males?
Does age affect the venodilatory response to isoproterenol and PGE1 in healthy males?
The age-related decline in vascular responsiveness is specific to beta-adrenoceptor agonists and does not affect adenylate cyclase coupled receptors like PGE1.
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Isoproterenol venodilation declines with age while PGE1 response is preserved; leaves open receptor-specific mechanisms and clinical relevance in older adults.
Hiremath et al. (1989) studied this question.
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