Key result
Advancing age was associated with a greater decline in contractile response to isoproterenol in men (FS-sigma es slope -0.87 in young vs -0.41 in older) than in women (-0.55 vs -0.38).
Why the study?
Do age and gender affect the inotropic and chronotropic responses to beta-adrenergic stimulation with isoproterenol in healthy individuals?
Cross-Sectional (n=36)
Do age and gender affect the inotropic and chronotropic responses to beta-adrenergic stimulation with isoproterenol in healthy individuals?
Men exhibit a significantly greater age-associated decline in inotropic and chronotropic responses to beta-adrenergic stimulation compared to women.
No takes yet. Share an insight, caveat, or question.
May support sex-specific age effects on beta-adrenergic responsiveness; hypothesis-generating and should not yet change practice.
Turner et al. (1999) conducted a cross-sectional in Healthy (n=36). Advancing age and male gender vs. Young age and female gender was evaluated on Slopes of the fractional shortening-end-systolic wall stress (FS-sigma es) relationships. Advancing age was associated with a greater decline in contractile response to isoproterenol in men (FS-sigma es slope -0.87 in young vs -0.41 in older) than in women (-0.55 vs -0.38).
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