Population
Single myocytes from non-failing human left ventricle obtained from patients undergoing coronary artery…
Comparison
In vitro exposure to isoproterenol and high Ca2+ vs Myocytes from younger subjects (<40 years)
Design
Preclinical
Authors
Loading...
Suggests age-related beta-adrenergic impairment in myocytes; hypothesis-generating and should not change practice without clinical validation.
Age and/or coronary disease selectively reduces the maximum contractile effect of beta-adrenoceptor stimulation by isoproterenol in non-failing human ventricular myocytes.
Davies et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: