Why the study?
Does senescence reduce the contractile response of isolated cardiac myocytes to norepinephrine?
Population
Individual isolated left ventricular cardiac myocytes from hearts of animals aged 2, 6-8, and 24 months
Comparison
Norepinephrine, increased bathing [Ca2+], BAY K… vs Baseline and comparison across age groups
Design
Preclinical
Authors
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Senescence attenuates myocyte beta-adrenergic responsiveness in rodents; leaves open relevance to human cardiac aging or therapy.
Does senescence reduce the contractile response of isolated cardiac myocytes to norepinephrine?
The age-associated decline in cardiac myocyte contractile response to beta-adrenergic stimulation is specific to the beta-adrenergic pathway and cAMP production.
Sakai et al. (1992) studied this question.
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