Population
Pekin ducks, including congenitally infected birds (up to 2 years of age) and adolescent ducks.
Comparison
Intravenous inoculation with a large dose of… vs Congenital chronic infection
Design
Preclinical
Follow-up
up to 2 years
Authors
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Hypothesis-generating for non-cytolytic hepadnavirus clearance; leaves open translation to human HBV.
Clearance of hepadnavirus infection can occur rapidly without massive hepatocyte death, suggesting non-cytolytic mechanisms of viral clearance.
Jilbert et al. (1992) studied this question.
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