Adherent hybrids between immunoglobulin-producing mouse myeloma cells and fibroblasts do not produce immunoglobulin polypeptide chains. These hybrids retained the actively rearranged immunoglobulin genes of the myeloma parental cells but lacked immunoglobulin heavy- and light-chain RNA transcripts. We conclude that the shutoff of immunoglobulin production in these hybrids occurs at the transcription or early processing level.
No takes yet. Share an insight, caveat, or question.
Greenberg et al. (1987) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: