What question did this study set out to answer?

To summarize the mechanisms of action, chemical characteristics, and anticancer efficacy of human dihydrofolate reductase (DHFR) inhibitors developed over a six-year period.

March 22, 2019MoleculesOpen Access

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

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To summarize the mechanisms of action, chemical characteristics, and anticancer efficacy of human dihydrofolate reductase (DHFR) inhibitors developed over a six-year period.
Reviewed medicinal chemistry literature detailing DHFR inhibitors identified across a six-year interval.
Assessed chemical structures and biochemical principles regulating target enzyme selectivity and antiproliferative activity.
Identified advanced chemical scaffolds and drug design strategies that facilitate the generation of selective human DHFR inhibitors.
Summarized mechanistic approaches that enhance antiproliferative activity against malignant cells while mitigating non-specific toxicity.

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Implication

Review uncovers novel human dihydrofolate reductase inhibitors and chemical strategies in cancer chemotherapy, highlighting pathways for selective drug discovery.

Cite This Study

Raimondi et al. (2019) studied this question.

synapsesocial.com/papers/6a6f2c0f75498292b70891ce https://doi.org/10.3390/molecules24061140

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Implication

Review uncovers novel human dihydrofolate reductase inhibitors and chemical strategies in cancer chemotherapy, highlighting pathways for selective drug discovery.

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

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Discussion

Implication

Cite This Study

DHFR Inhibitors: Reading the Past for Discovering Novel Anticancer Agents

Key Points

Discussion

Implication

Cite This Study

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