If information is not in digital form, it may as well not exist for today's researchers. That is what we have heard from those who oversee medical and scientific libraries. For several centuries, doing serious research meant spending hours in a major library, usually deep in the solitude of the stacks, exploring through heavy, bound volumes of the print literature. There was no alternative. And until this summer, for readers of the Journal there was no alternative for all that was published before 1993, since that is where the full-text online archive began. That has now changed. At NEJM.org, every issue of the Journal is available in electronic form all the way back to the first article, "Remarks on Angina Pectoris" by John Warren,
No takes yet. Share an insight, caveat, or question.
Campion et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: