The origin of both the basic (tropane derivatives) and acidic (tropic acid, tiglic acid, benzoic acid) moieties of these ester alkaloids is reviewed. Subsequent metabolism (mostly by oxidation reactions) of the tropine half of these alkaloids is discussed. Key Word Index Tropane Alkaloids - Biosynthesis - Metabolism - Tropic Acid - Tiglic Acid - Hydroxylation of Tropine
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Edward Leete (1979) studied this question.