September 1, 1992Clinical Science
Nyctohemeral changes in bone turnover assessed by serum bone Gla-protein concentration and urinary deoxypyridinoline excretion: effects of growth and ageing
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Discussion
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Implication
Observational study reveals diurnal rhythms in bone turnover across pubertal, premenopausal, and postmenopausal females, indicating heightened nocturnal bone resorption.
Key Points
- To investigate whether a nyctohemeral (day-night) rhythm exists in bone turnover and how it is influenced by growth and ageing.
- Evaluated 42 females across three groups: 10 pubertal girls (aged 10–14 years), 15 premenopausal women (aged 20–49 years), and 17 postmenopausal women (aged 50–75 years).
- Measured serum bone Gla-protein (osteocalcin) every 2 hours and urinary deoxypyridinoline excretion over 8-hour intervals, alongside urinary electrolytes and serum parathyroid hormone levels.
- Pubertal girls demonstrated 5-fold higher serum Gla-protein and urinary deoxypyridinoline than premenopausal women, while postmenopausal women showed 2-fold higher deoxypyridinoline excretion than premenopausal women.
- A nyctohemeral rhythm was observed across all age groups, characterized by a mean night-time increase of 28% in urinary deoxypyridinoline (P < 0.001) and 5% in serum bone Gla-protein (P < 0.001).
- Urinary excretion of calcium (P < 0.02), sodium (P < 0.001), and potassium (P < 0.001) decreased at night, while serum parathyroid hormone peaked during the afternoon and night, rising with age specifically between 01:00 and 07:00.
Cite This Study
Eastell et al. (1992) studied this question.