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February 9, 1998Circulation ResearchOpen Access

Possible Involvement of Stress-Activated Protein Kinase Signaling Pathway and Fas Receptor Expression in Prevention of Ischemia/Reperfusion-Induced Cardiomyocyte Apoptosis by Carvedilol

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Why the study?

Does carvedilol prevent ischemia/reperfusion-induced cardiomyocyte apoptosis in anesthetized rabbits?

Population

Anesthetized rabbits subjected to 30 minutes of coronary artery occlusion followed by 4 hours of reperfusion

Comparison

Carvedilol administered 5 minutes before… vs Vehicle, and propranolol administered at…

Design

Preclinical

Follow-up

4 hours of reperfusion

Authors

TYTian-Li YueNew FrontierXMXin-Liang MaThomas Jefferson UniversityXWXinkang WangSouthern University of Science and Technology

Discussion

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Implication

Attenuates apoptosis in rabbit I/R model; leaves open translation to human cardioprotection.

Structured PICO

Does carvedilol prevent ischemia/reperfusion-induced cardiomyocyte apoptosis in anesthetized rabbits?

P
Population
Anesthetized rabbits subjected to 30 minutes of coronary artery occlusion followed by 4 hours of reperfusion
I
Intervention
Carvedilol (1 mg/kg IV) administered 5 minutes before reperfusion
C
Comparator
Vehicle, and propranolol (1 mg/kg) administered at equipotent beta-blocking dosage
O
Outcome
Apoptosis of cardiomyocytes (measured by nucleosomal DNA fragments on agarose gels and in situ nick end labeling)surrogate

Carvedilol prevents myocardial ischemia/reperfusion-induced apoptosis in cardiomyocytes, possibly by downregulating the SAPK signaling pathway and inhibiting Fas receptor expression.

Cite This Study

Yue et al. (1998) studied this question.

synapsesocial.com/papers/6a6f2e8635aa2c282ce096b8https://doi.org/10.1161/01.res.82.2.166
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.1995 · 399 citations
  2. 2Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia1996 · 420 citations
  3. 3Apoptosis in the Heart1996 · 136 citations
  4. 4The Fas Death Factor1995 · 4,022 citations