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December 1, 1994The Journal of Experimental MedicineOpen Access

Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane.

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Population

31 BALB/c mice (11 injected with pristane, 20 age- and sex-matched controls)

Comparison

Single intraperitoneal injection of 0.5 ml… vs No injection

Design

Preclinical

Follow-up

6 months

Authors

MSMasataka SatohFukushima Medical UniversityWRWestley H. ReevesUniversity of Florida Health

Discussion

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Overview

Supports inducible murine SLE models; leaves open human translation and mAb contamination risks.

Structured PICO

P
Population
31 BALB/c mice (11 injected with pristane, 20 age- and sex-matched controls)
I
Intervention
Single intraperitoneal injection of 0.5 ml pristane (2,6,10,14 tetramethylpentadecane)
C
Comparator
No injection (20 BALB/c mice of the same age and sex)
O
Outcome
Production of autoantibodies characteristic of systemic lupus erythematosus (SLE) including anti-Su, anti-U1RNP, anti-U2RNP, anti-Sm, and anti-U5RNPsurrogate

Pristane injection induces lupus-associated autoantibodies in BALB/c mice, providing a model for autoimmune pathogenesis and highlighting the risk of autoantibody contamination in ascitic fluid-derived monoclonal antibodies.

Cite This Study

Satoh et al. (1994) studied this question.

synapsesocial.com/papers/6a6f2e8dce524a4339c334e4https://doi.org/10.1084/jem.180.6.2341
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp- lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.1994 · 73 citations
  2. 2Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies.1984 · 30 citations
  3. 320S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition.1989 · 148 citations
  4. 4Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.1987 · 355 citations
  5. 5V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice1993 · 81 citations