Key result
Transient myocardial ischemia during prolonged PTCA considerably decreased the fractal scalar exponent alpha(1) and power-law slope beta, indicating a reduction in ANS complexity.
Why the study?
Does transient myocardial ischemia during prolonged PTCA alter the autonomic nervous system response as measured by heart rate variability?
Observational (n=50)
Does transient myocardial ischemia during prolonged PTCA alter the autonomic nervous system response as measured by heart rate variability?
Transient myocardial ischemia during PTCA significantly alters autonomic control of the heart rate, reducing the complexity of the autonomic nervous system.
Ischemia during PTCA was associated with reduced ANS complexity; leaves open whether fractal HRV metrics aid procedural risk stratification.
Coronary artery occlusions related to myocardial ischemia drive cardiac control system reactions that may lead to heart failure. The purpose of this study was to assess the autonomic nervous system (ANS) response during prolonged percutaneous transluminal coronary angioplasty (PTCA). Continuous ECG data were acquired from 50 patients before and during PTCA, with occlusions in the left anterior descending, left circumflex or right coronary artery. Heart rate variability (HRV) was analyzed for 3-min segments of the R-R interval signal obtained from ECG data. The ANS behavior was evaluated by HRV analysis using fractal-like indices. The fractal scalar exponent alpha(1) and power-law slope beta decreased considerably during PTCA. This indicates that significant reactions of autonomic control of the heart rate occurred during coronary artery occlusions, with a reduction in complexity of the ANS.
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Gomis et al. (2006) conducted an observational in Transient myocardial ischemia (n=50). Transient myocardial ischemia during PTCA vs. Before PTCA (baseline) was evaluated on Autonomic nervous system response evaluated by heart rate variability using fractal-like indices (fractal scalar exponent alpha(1) and power-law slope beta). Transient myocardial ischemia during prolonged PTCA considerably decreased the fractal scalar exponent alpha(1) and power-law slope beta, indicating a reduction in ANS complexity.
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