Key result
Pre-discharge total power heart rate variability index showed prognostic accuracy for major clinical events at 3 months in male patients with acute coronary syndrome (AUC 0.748; p=0.040).
Why the study?
The predictive value of pre-discharge heart rate variability parameters in patients with ACS treated with PCI needed to be evaluated.
Does pre-discharge heart rate variability predict major clinical events in male patients with acute coronary syndrome treated by PCI?
Cohort (n=145)
Does pre-discharge heart rate variability predict major clinical events in male patients with acute coronary syndrome treated by PCI?
Pre-discharge total power heart rate variability index offers modest prognostic accuracy for predicting 3-month major clinical events in male patients with acute coronary syndrome undergoing PCI.
Answers are grounded in this paper and cite their sources.
May refine short-term prognostication after ACS in males; leaves open added value and prospective validation.
OBJECTIVES: To assess the predictive value of pre-discharge heart rate variability (HRV) parameters in patients with acute coronary syndrome (ACS) treated by percutaneous coronary intervention (PCI). METHODS: 145 consecutive male patients with ACS (aged 57.12 ± 10.81 years) were included in this study. Fifteen minutes electrocardiogram recording was done to measure time-domain [standard deviation of N-N intervals (SDNN), root-mean square differences of successive R-R intervals (rMSSD)] and frequency-domain [low-frequency (LF) power, high-frequency (HF) power and total power (TP)] HRV parameters before and after PCI. The primary end point was the occurrence of major clinical events (MCE) defined as death, sudden death or re-acute myocardial infarction at the end of 3 months follow-up. RESULTS: At a follow-up of 3 months, MCE occurred in 06 patients (4.14%) (Cardiac death was 3.01%, while that of sudden death was 1.13%). Out of six-MCE, four deaths and two re-AMIs occurred. Pre-discharge HRV values (SDNN, rMSSD, TP, LF and HF) were significantly lower in patients with ACS without MCE. Only total power HRV index (AUC=0.748; p=0.040) showed greater prognostic accuracy. CONCLUSIONS: In conclusion, study showed an increase in SDNN, rMSSD, LF, HF and TP after successful revascularization with PCI in patients who had MCE. The resultant sensitivity, specificity of HRV is still limited in the present study. Particularly, its sensitivity is higher (33-83%) with a modest specificity (61-72%).
No takes yet. Share an insight, caveat, or question.
Seetharam et al. (2022) conducted a cohort in acute coronary syndrome (n=145). Pre-discharge heart rate variability (HRV) was evaluated on Major clinical events (MCE) defined as death, sudden death or re-acute myocardial infarction at the end of 3 months follow-up (AUC 0.748, p=0.040). Pre-discharge total power heart rate variability index showed prognostic accuracy for major clinical events at 3 months in male patients with acute coronary syndrome (AUC 0.748; p=0.040).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: