Key result
Flavonoids induce vasodilation through multiple signaling pathways to confer therapeutic vascular effects.
Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.
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Rezende et al. (2015) conducted a review in Cardiovascular system (vasodilation). Flavonoids was evaluated on Signaling pathways involved in the molecular mechanisms underlying vasodilation. Flavonoids induce vasodilation through various molecular mechanisms and signaling pathways that underlie their therapeutic vascular effects.
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