Key result
US leads coronary-carotid atherosclerosis research, with artificial intelligence emerging as a major hotspot.
Why the study?
Early identification of coronary artery disease is challenging due to invasive and complex diagnostic methods, prompting evaluation of carotid artery assessment as a non-invasive CAD risk predictor.
This bibliometric analysis highlights a research shift from establishing anatomical coronary-carotid connections towards using non-invasive carotid assessments and AI for personalized CAD risk prediction.
US leads and AI emerges as hotspot in coronary-carotid research; leaves open prospective validation of carotid surrogates before clinical adoption.
BACKGROUND AND OBJECTIVES: The early identification of coronary artery disease (CAD) is a challenging task. Direct diagnosis of CAD often requires invasive procedures and complex and expensive imaging techniques. The carotid artery is superficial. It can be easily examined with non-invasive ultrasound. This makes it a potential "window" for overall arterial health and CAD risk. This study uses bibliometric methods. It reviews and visualizes research on the correlation between the coronary and carotid arteries. The goal is to show the field's development, identify research hotspots, and evaluate the use of carotid assessment in CAD risk prediction. MATERIALS AND METHODS: We retrieved and included 419 studies on the coronary-carotid correlation published between January 1, 2005, and September 26, 2025, from the Web of Science Core Collection (WoSCC). Bibliometric analysis and visualization were performed using CiteSpace, VOSviewer, and the R package. RESULTS: This study analyzed 419 publications from 62 countries, 890 institutions, and 2,885 authors, published across 204 journals. The United States leads research in this domain. The University of Washington in the U.S. and Queen's University in Canada were the most productive institutions. The most prolific author was SABA L from the University of Cagliari, Italy, with 18 published papers and 516 co-citations. Research output in this area continues to grow. Atherosclerosis published the most articles on this topic, with 39 publications. The core keywords in this field are atherosclerosis, intima-media thickness, prediction, coronary artery disease, and associations. The latest hotspots are atherosclerosis risk assessment, the carotid artery as a coronary 'window' and surrogate marker, and "machine learning" and "deep learning" for precision diagnosis and treatment. DISCUSSION: The analysis shows the carotid artery is a useful tool for assessing overall CAD risk. The research focus has clearly changed. It moved from proving anatomical connections to using this knowledge for personal patient predictions. Applying artificial intelligence to the indicator detection of coronary arteries and carotid arteries is expected to enhance the diagnostic level of coronary artery diseases. AI-assisted ultrasound imaging technology may have a profound impact on the diagnosis and treatment of cardiovascular diseases. CONCLUSIONS: Future work should strengthen broader regional cooperation and forward-looking validation, developing towards more precise and automated approaches to ensure measurable patient benefits.
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Li et al. (2026) conducted a review in Coronary artery disease (n=419). Bibliometric analysis was evaluated on Research trends, productivity, and hotspots. A bibliometric analysis of 419 publications identified the United States as the leading contributor and artificial intelligence as an emerging hotspot in coronary-carotid correlation research.
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