Key result
Initiation of clozapine therapy in a 49-year-old man resulted in profound shock, severe left ventricular systolic dysfunction, and elevated creatine kinase, which resolved upon drug discontinuation.
Case Report (n=1)
Initiation of clozapine can cause life-threatening adverse reactions presenting as profound shock and severe left ventricular systolic dysfunction, necessitating high clinical suspicion and prompt drug discontinuation.
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Clozapine initiation may trigger reversible cardiogenic shock; this case report leaves open incidence and causality in broader populations.
Howard A. Greller (2014) conducted a case report in Schizoaffective disorder (n=1). Clozapine was evaluated. Initiation of clozapine therapy in a 49-year-old man resulted in profound shock, severe left ventricular systolic dysfunction, and elevated creatine kinase, which resolved upon drug discontinuation.
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