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April 1, 1991Archives of Internal Medicine

Three cases of neuroleptic malignant syndrome were identified following the withdrawal of levodopa therapy in patients with Parkinson's disease.

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Why the study?

Does withdrawal or reduction of levodopa therapy cause neuroleptic malignant syndrome in patients with Parkinson's disease?

Population

3 patients with Parkinson's disease

Design

Case_series

Authors

DKDaniel L. Keyser

Discussion

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Overview

Caution warranted with levodopa withdrawal in PD; leaves open causality pending controlled studies.

Structured PICO

Does withdrawal or reduction of levodopa therapy cause neuroleptic malignant syndrome in patients with Parkinson's disease?

P
Population
3 patients with Parkinson's disease
I
Intervention
Withdrawal or reduction of levodopa therapy or other dopaminergic drug therapy
O
Outcome
Neuroleptic malignant syndromesafety

Withdrawal or alteration of dopaminergic therapy in Parkinson's disease can precipitate potentially fatal neuroleptic malignant syndrome, highlighting the need for careful medication management.

Cite This Study

Daniel L. Keyser (1991) studied this question.

synapsesocial.com/papers/6a6f3118ac440176ef27e729https://doi.org/10.1001/archinte.1991.00400040130031
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