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May 1, 1981The Journal of Nervous and Mental Disease

Neuroleptic Malignant Syndrome-like State Following a Withdrawal of Antiparkinsonian Drugs

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Population

1 63-year-old woman with Parkinson's disease who developed a neuroleptic malignant syndrome-like state…

Comparison

L-dopa and carbidopa vs Initial 14 days of treatment with intravenous…

Design

Case_report

Authors

MTMichio ToruOMOsamu MatsudaKMK Makiguchi

Discussion

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Overview

May support dopaminergic trial in refractory withdrawal states; leaves open confirmation in controlled studies.

Structured PICO

P
Population
1 63-year-old woman with Parkinson's disease who developed a neuroleptic malignant syndrome-like state following the discontinuation of large doses of combined antiparkinsonian drugs.
I
Intervention
L-dopa and carbidopa
C
Comparator
Initial 14 days of treatment with intravenous fluids and antibiotics
O
Outcome
Clinical improvement of symptoms

L-dopa and carbidopa can effectively treat neuroleptic malignant syndrome-like states induced by the withdrawal of antiparkinsonian drugs, suggesting dopaminergic hypoactivity as a shared underlying mechanism.

Cite This Study

Toru et al. (1981) studied this question.

synapsesocial.com/papers/6a817a40e83875aedff092a2https://doi.org/10.1097/00005053-198105000-00011
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