Key result
Levodopa withdrawal in a 60-year-old woman with Parkinson's disease resulted in a fatal neuroleptic malignant syndrome accompanied by myoglobinuric renal failure.
Population
1 60-year-old woman with idiopathic Parkinson's disease and schizophrenia
Design
Case_report
Follow-up
1 week
Authors
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Abrupt levodopa withdrawal may precipitate fatal NMS-like illness in Parkinson's; leaves open whether prospective studies should define safe tapering protocols.
Case Report (n=1)
Levodopa withdrawal in Parkinson's disease may cause a syndrome identical to neuroleptic malignant syndrome due to the loss of dopaminergic drive.
Gibb et al. (1986) conducted a case report in Parkinson's disease (n=1). Levodopa (Sinemet) withdrawal was evaluated on Development of neuroleptic malignant syndrome (NMS). Levodopa withdrawal in a 60-year-old woman with Parkinson's disease resulted in a fatal neuroleptic malignant syndrome accompanied by myoglobinuric renal failure.
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