What question did this study set out to answer?

To evaluate the independent and combined associations of serum selenium, vitamin A (retinol), and vitamin E (alpha tocopherol) concentrations with fatal cancer risk.

February 9, 1985BMJOpen Access

Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.

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Authors

JSJ T SalonenKuopio University Hospital RSRiitta SalonenMerck & Co., Inc., Rahway, NJ, USA (United States)RLRaili LappeteläinenTampere University

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Implication

Matched case-control study reveals increased cancer mortality risk with low serum selenium and vitamins A and E in Finnish adults, indicating dietary micronutrients may protect against fatal cancer.

Key Points

To evaluate the independent and combined associations of serum selenium, vitamin A (retinol), and vitamin E (alpha tocopherol) concentrations with fatal cancer risk.
Conducted a prospective matched case-control study derived from a random sample of approximately 12,000 residents aged 30–64 years in eastern Finland followed for four years.
Identified and analyzed 51 cancer mortality cases paired 1:1 with controls matched for age, sex, and smoking status.
Patients who died from cancer had a 12% lower mean serum selenium concentration compared with controls (p = 0.015), which persisted after excluding deaths occurring in the first follow-up year.
The adjusted risk of fatal cancer was 5.8-fold (95% CI, 1.2–29.0) in the lowest selenium tertile compared with higher tertiles.
Subjects with combined low serum selenium and low alpha tocopherol exhibited an 11.4-fold adjusted risk of fatal cancer, and smoking men who died of cancer had 26% lower serum retinol levels than smoking controls (p = 0.002).

Cite This Study

Salonen et al. (1985) studied this question.

synapsesocial.com/papers/6a6f328575498292b70898d7 https://doi.org/10.1136/bmj.290.6466.417

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Implication

Matched case-control study reveals increased cancer mortality risk with low serum selenium and vitamins A and E in Finnish adults, indicating dietary micronutrients may protect against fatal cancer.

Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.

Discussion

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Implication

Key Points

Cite This Study

Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prospective data.

Discussion

Member takes

Implication

Key Points

Cite This Study

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