Assessment of left ventricular filling pressure and its correlation with severity of chronic kidney disease

Aims: This study was aimed to assess the left ventricular filling pressure (LVFP) and its relationship with severity of chronic kidney disease (CKD). Methods: One hundred CKD patients were subjected to standard echocardiography and the new modality of tissue Doppler imaging. The LVFP is calculated with E/e' ratio (early diastolic mitral inflow velocity – E to early diastolic mitral annulus velocity – e'). All these patients were divided into five subgroups depending on their estimated glomerular filtration rate (eGFR: ml/min/body surface area). Results: The analysis of echocardiographic parameters (E and e') showed that in CKD patients, the stage of renal failure was associated with the significant increase in LVFP with P < 0.001. There was a significant correlation between LVFP and eGFR with r = −0.467 and P < 0.001. Conclusion: These data suggest that LVFP starts to raise early in the case of CKD. The increase in LVFP is directly proportional to the severity of renal failure.