Key result
Untreated hypothyroidism was associated with significantly higher central arterial stiffness compared to controls (augmentation index 32.0% vs 17.0%; P<0.0005), which improved after T4 replacement.
Why the study?
Does T4 replacement therapy improve central arterial stiffness in patients with hypothyroidism?
Population
12 untreated hypothyroid patients and 12 age-, sex-, and body mass index-matched controls (total n=24).
Comparison
T4 replacement therapy for 6 months vs Age-, sex-, and BMI-matched controls and…
Design
Cohort
Follow-up
6 months
Authors
Loading...
May support T4 to reverse stiffness in hypothyroidism; leaves open randomized outcome trials.
Case-Control (n=24)
Does T4 replacement therapy improve central arterial stiffness in patients with hypothyroidism?
Absolute Event Rate: 32% vs 17%
p-value: p=<0.0005
Hypothyroidism is associated with increased central arterial stiffness, which is reversible with adequate T4 replacement therapy.
Obuobie et al. (2002) conducted a case-control in Hypothyroidism (n=24). Hypothyroidism vs. Matched controls was evaluated on Augmentation index (AI) (p=<0.0005). Untreated hypothyroidism was associated with significantly higher central arterial stiffness compared to controls (augmentation index 32.0% vs 17.0%; P<0.0005), which improved after T4 replacement.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: