Key result
The system inflammation response index (SIRI) was a significant prognostic factor for major adverse cardiovascular events in patients with intermediate coronary stenosis (HR 1.588; 95% CI 1.138-2.212).
Why the study?
Complete blood count-derived inflammatory indices have been proposed to predict outcomes in coronary artery disease but have yet to be thoroughly validated in patients with intermediate coronary stenosis.
Do complete blood count-derived indices predict major adverse cardiovascular events in patients with intermediate coronary stenosis?
Cohort (n=1,527)
Do complete blood count-derived indices predict major adverse cardiovascular events in patients with intermediate coronary stenosis?
Hazard Ratio: 1.588 (95% CI 1.138–2.212)
Systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) provide significant prognostic value for predicting MACE in patients with intermediate coronary stenosis, offering incremental value beyond traditional risk models.
May inform risk stratification in intermediate stenosis; hypothesis-generating and needs prospective validation.
Complete blood count (CBC)-derived indices have been proposed as reliable inflammatory biomarkers to predict outcomes in the context of coronary artery disease. These indices have yet to be thoroughly validated in patients with intermediate coronary stenosis. Our study included 1527 patients only with intermediate coronary stenosis. The examined variables were neutrophil-lymphocyte ratio (NLR), derived NLR, monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). The primary endpoint was the composite of major adverse cardiovascular events (MACEs), including all-cause death, non-fatal myocardial infarction, and unplanned revascularization. Over a follow-up of 6.11 (5.73-6.55) years, MACEs occurred in 189 patients. Receiver operator characteristic curve analysis showed that SIRI outperformed other indices with the most significant area under the curve. In the multivariable analysis, SIRI (hazard ratio [HR] 1.588, 95% confidence interval [CI] 1.138-2.212) and AISI (HR 1.673, 95% CI 1.217-2.300) were the most important prognostic factors among all the indices. The discrimination ability of each index was strengthened in patients with less burden of modifiable cardiovascular risk factors. SIRI also exhibited the best incremental value beyond the traditional cardiovascular risk model.
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Yang et al. (2023) conducted a cohort in Intermediate coronary stenosis (n=1,527). System inflammation response index (SIRI) was evaluated on Composite of major adverse cardiovascular events (MACEs), including all-cause death, non-fatal myocardial infarction, and unplanned revascularization (HR 1.588, 95% CI 1.138-2.212). The system inflammation response index (SIRI) was a significant prognostic factor for major adverse cardiovascular events in patients with intermediate coronary stenosis (HR 1.588; 95% CI 1.138-2.212).
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