Case report observes diffuse large B-cell lymphoma with cutaneous involvement in xeroderma pigmentosum type C, highlighting severe malignancy risks from impaired DNA repair.
Xeroderma pigmentosum type C (XP-C) is a rare autosomal recessive genetic disorder characterized by an inability to repair DNA damage caused by ultraviolet (UV) radiation. Individuals with XP-C have a heightened susceptibility to skin cancer because their genetic mutation hinders the repair of DNA damage induced by exposure to UV radiation.1 XP poses a significant health risk to affected individuals, making UV protection and regular screenings vital components of their care.2
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