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That HIV is able to escape the antibody response of the human immune system is well established. In a Perspective, [McMichael and Klenerman][1] explain new work ([ Moore et al .][2]) providing evidence that HIV is able to mutate crucial epitopes, thus enabling the virus also to evade the host CTL immune response. [1]: http://www.sciencemag.org/cgi/content/full/296/5572/1410 [2]: http://www.sciencemag.org/cgi/content/short/296/5572/1439
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McMichael et al. (2002) studied this question.
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