Why the study?
Does allogeneic bone marrow transplantation lead to loss of protective immunity to polio, diphtheria, and Haemophilus influenzae type b in adult recipients?
Population
16 adult recipients of a bone marrow transplant from an HLA-identical sibling donor (no T-cell depletion)
Comparison
Allogeneic bone marrow transplantation vs Pre-transplant baseline
Design
Cohort
Follow-up
12 months
Authors
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Adult allogeneic BMT recipients may lose polio and diphtheria immunity; hypothesis-generating for revaccination protocols pending larger studies.
Does allogeneic bone marrow transplantation lead to loss of protective immunity to polio, diphtheria, and Haemophilus influenzae type b in adult recipients?
Adult recipients of allogeneic bone marrow transplants lose protective immunity to polio, diphtheria, and Haemophilus influenzae type b, indicating a need for revaccination.
Parkkali et al. (1996) studied this question.
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