Key result
Blood pressure variability is an independent risk factor for target organ damage and cardiovascular events, and antihypertensive therapy should aim to reduce both mean blood pressure and its fluctuation.
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Blood pressure variability is an independent risk factor for target organ damage and cardiovascular events, and its reduction should be a therapeutic target alongside absolute blood pressure lowering.
Authors have collected and analyzed literature data on blood pressure variability. They present the methods of blood pressure variability measurement, clinical value and relationships with target organ damages and risk of presence of cardiovascular events. They collect data about the prognostic value of blood pressure variability and the effects of different antihypertensive drugs on blood pressure variability. They underline that in addition to reduction of blood pressure to target value, it is essential to influence blood pressure fluctuation and decrease blood pressure variability, because blood pressure fluctuation presents a major threat for the hypertensive subjects. Data from national studies are also presented. They welcome that measurement of blood pressure variability has been included in international guidelines.
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Kékes et al. (2014) conducted a review in Hypertension and blood pressure variability. Blood pressure variability measurement and management was evaluated. Blood pressure variability is an independent risk factor for target organ damage and cardiovascular events, and antihypertensive therapy should aim to reduce both mean blood pressure and its fluctuation.
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