Key result
HLA DQB1*0303 polymorphism was significantly associated with myocarditis without cardiac dysfunction, while HLA DQB1*0301 and absence of HLA DQB1*06 were weakly associated with inflammatory DCM.
Why the study?
Is HLA-DQB1* polymorphism associated with specific types of dilated cardiomyopathy and myocarditis?
Case-Control (n=101)
Is HLA-DQB1* polymorphism associated with specific types of dilated cardiomyopathy and myocarditis?
Specific HLA-DQB1* alleles may help distinguish between idiopathic DCM, inflammatory DCM, and myocarditis with or without cardiac dysfunction.
HLA-DQB1 typing may aid myocarditis subtyping; hypothesis-generating and requires validation before any clinical use.
To date, only weak associations have been reported between idiopathic dilated cardiomyopathy (DCM) and certain HLA class II alleles. Associations between HLA class II alleles and specific causes of DCM, especially myocarditis, have as yet not been systematically investigated. Typing of HLA DQB1* allele was performed using a sequence-specific primer-polymerase chain reaction technique in 22 unrelated patients with idiopathic DCM, 19 patients with myocarditis and normal left ventricular function, and 16 patients with myocarditis and impaired left ventricular function (i.e. inflammatory DCM). Controls comprised 44 patients without (inflammatory) cardiac disease and a population control. A significant association was found for presence of HLA DQB1*0303 with myocarditis without cardiac dysfunction. Weaker associations were seen for presence of HLA DQB1*0301 and absence of HLA DQB1*06 with inflammatory DCM. Additionally, allelic combination DQB1*02-DQB1*03 may be able to distinguish idiopathic from inflammatory DCM, and HLA DQB1*02 myocarditis with cardiac dysfunction from myocarditis without, if results are confirmed by larger prospective studies.
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Portig et al. (2009) conducted a case-control in Dilated cardiomyopathy and myocarditis (n=101). HLA-DQB1* polymorphism vs. Controls without cardiac disease was evaluated on Association between HLA DQB1* alleles and specific causes of DCM or myocarditis. HLA DQB1*0303 polymorphism was significantly associated with myocarditis without cardiac dysfunction, while HLA DQB1*0301 and absence of HLA DQB1*06 were weakly associated with inflammatory DCM.
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