What question did this study set out to answer?

To evaluate HLA antigen distribution differences between familial and non-familial dilated cardiomyopathy to determine its value as a risk-screening marker.

June 1, 1997HeartOpen Access

Idiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.

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Why the study?

Is the HLA-DR4 haplotype associated with a familial predisposition to dilated cardiomyopathy?

Population

100 patients with dilated cardiomyopathy, 200 first-degree relatives from 56 of the proband families, and…

Comparison

HLA profiling vs Normal controls and patients with non-familial…

Design

Case-control

Authors

CMCharles J. McKennaInterventional / Structural Cardiology MCMary CoddUniversity College Dublin HMH. McCannMater Misericordiae University Hospital

Discussion

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Implication

May indicate HLA-linked predisposition in familial dilated cardiomyopathy; leaves open causal role and clinical utility.

Key Points

To evaluate HLA antigen distribution differences between familial and non-familial dilated cardiomyopathy to determine its value as a risk-screening marker.
Screened 200 first-degree relatives across 56 proband families with echocardiography to identify familial dilated cardiomyopathy.
Compared HLA profiles among 100 dilated cardiomyopathy patients, familial (n=25) versus non-familial (n=31) subgroups, and 9,000 normal controls.
Familial dilated cardiomyopathy prevalence was classified as definite in 25% (14 of 56) and possible in 45% (25 of 56) of evaluated families.
Overall HLA-DR4 frequency in 100 patients with dilated cardiomyopathy was 39% compared to 32% in 9,000 normal controls.
HLA-DR4 frequency was significantly higher in probands with familial dilated cardiomyopathy than in non-familial cases (68% vs 32%; P < 0.05).

Structured PICO

Is the HLA-DR4 haplotype associated with a familial predisposition to dilated cardiomyopathy?

Population

100 patients with dilated cardiomyopathy, 200 first-degree relatives from 56 of the proband families, and 9000 normal controls.

Intervention

HLA profiling

Comparator

Normal controls and patients with non-familial dilated cardiomyopathy

Outcome

HLA distribution (specifically HLA-DR4 frequency)surrogate

The HLA-DR4 haplotype is significantly more common in familial cases of dilated cardiomyopathy, suggesting an HLA-linked genetic predisposition.

Cite This Study

McKenna et al. (1997) studied this question.

synapsesocial.com/papers/6a910ecd17bbbfe73e745785 https://doi.org/10.1136/hrt.77.6.549

Topics

Echocardiography

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Idiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Idiopathic dilated cardiomyopathy: familial prevalence and HLA distribution.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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