Population
236 relatives from 40 families of patients with dilated cardiomyopathy, and 239 healthy controls. Relatives…
Comparison
Screening consisting of clinical examination, 12… vs 239 healthy controls
Design
Cross-sectional, All echocardiograms were performed by an experienced…
Authors
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Supports family screening for subclinical LV abnormalities in DCM; leaves open prospective validation of progression and thresholds.
Familial dilated cardiomyopathy is common, affecting 25% of families, and appears to be transmitted via an autosomal dominant gene with variable penetrance, often presenting with minor echocardiographic abnormalities in apparently healthy relatives.
Keeling et al. (1995) studied this question.
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