Key result
The HLA-DRB1*1401 allele was associated with increased risk of idiopathic dilated cardiomyopathy (OR 2.6; 95% CI 1.11-6.11), whereas HLA-DRB1*0301 was associated with lower risk (OR 0.49).
Why the study?
Is HLA-DRB1 gene polymorphism associated with idiopathic dilated cardiomyopathy?
Meta-Analysis
Is HLA-DRB1 gene polymorphism associated with idiopathic dilated cardiomyopathy?
Odds Ratio: 2.6 (95% CI 1.11–6.11)
p-value: p=<0.05
The HLA-DRB1*1401 allele is associated with an increased risk of idiopathic dilated cardiomyopathy, whereas the *0901 and *0301 alleles may be protective.
Supports HLA-DRB1 variants as DCM susceptibility markers; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE: Some studies have reported that the HLA-DRB1 allele was associated with idiopathic dilated cardiomyopathy. However, there have been inconsistent results among different studies. To clarify the association of HLA-DRB1 and idiopathic dilated cardiomyopathy, a meta-analysis of case-control studies was performed. METHODS: PubMed database, Science Citation Index database, The Cochrane Central Register of Controlled Trials database, China National Knowledge Information database, Chinese Biomedical Literature database, Wanfang database, and VIP database in China were searched. Search terms included dilated cardiomyopathy and DRB1. Five case-control studies were included in the present meta-analysis to assess the association between HLA-DRB1*1401, HLA-DRB1*0901, HLA-DRB1*0301, and idiopathic dilated cardiomyopathy. RESULTS: A total of four studies were included in our meta-analysis for HLA-DRB1*1401 and HLA-DRB1*0901. The pooled odds ratio (OR) was 2.6 [95% confidence interval (CI) 1.11-6.11, P<0.05] and 0.70 (95% CI 0.48-1.00, P=0.05), respectively. For the HLA-DRB1*0301 allele, just three studies were included in our meta-analysis. The pooled OR was 0.49 (95% CI 0.27-0.91, P<0.05). The present meta-analysis indicated that the frequency of HLA-DRB1*1401 was higher in idiopathic dilated cardiomyopathy patients than in healthy people, whereas HLA-DRB1*0901 and HLA-DRB1*0301 were higher in healthy people than in idiopathic dilated cardiomyopathy patients. CONCLUSION: The HLA-DRB1*1401 allele might be a risk factor for idiopathic dilated cardiomyopathy and HLA-DRB1*0901 and HLA-DRB1*0301 might protect humans from idiopathic dilated cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
Deng et al. (2011) conducted a meta-analysis in idiopathic dilated cardiomyopathy. HLA-DRB1*1401 allele vs. healthy people was evaluated on idiopathic dilated cardiomyopathy (OR 2.6, 95% CI 1.11-6.11, p=<0.05). The HLA-DRB1*1401 allele was associated with increased risk of idiopathic dilated cardiomyopathy (OR 2.6; 95% CI 1.11-6.11), whereas HLA-DRB1*0301 was associated with lower risk (OR 0.49).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: