Key result
HLA-DR4, -DR15, and -DPB1*0601 alleles conferred susceptibility to idiopathic dilated cardiomyopathy, while the DPB1*0101 allele conferred protection in a Northern Chinese Han population.
Why the study?
Are HLA class II DRB1, DPA1, and DPB1 polymorphisms associated with genetic susceptibility to idiopathic dilated cardiomyopathy in the Chinese Han population?
Population
198 patients with idiopathic dilated cardiomyopathy and 136 randomly selected healthy Han ethnic individuals…
Comparison
DNA genotyping for HLA-DRB1, DPA1 and DPB1… vs Healthy controls
Design
Case-control
Authors
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Hypothesis-generating for HLA risk stratification in Northern Chinese Han; leaves open replication and broader validation before clinical use.
Case-Control (n=334)
Are HLA class II DRB1, DPA1, and DPB1 polymorphisms associated with genetic susceptibility to idiopathic dilated cardiomyopathy in the Chinese Han population?
HLA-DR4, -DR15, and -DPB1*0601 alleles confer susceptibility to idiopathic dilated cardiomyopathy, while the DPB1*0101 allele confers protection in the northern Chinese Han population.
Liu et al. (2006) conducted a case-control in Idiopathic dilated cardiomyopathy (n=334). HLA class II DRB1, DPA1 and DPB1 polymorphisms vs. Healthy controls was evaluated on Genetic susceptibility to idiopathic dilated cardiomyopathy. HLA-DR4, -DR15, and -DPB1*0601 alleles conferred susceptibility to idiopathic dilated cardiomyopathy, while the DPB1*0101 allele conferred protection in a Northern Chinese Han population.
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