Key result
Specific HLA antigens showed no significant association with idiopathic dilated cardiomyopathy or ischaemic heart disease when compared to controls.
Why the study?
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
Case-Control (n=1,125)
Do specific HLA antigens predispose to ischaemic heart disease or idiopathic dilated cardiomyopathy?
This study found no significant association between specific HLA antigens and the development of idiopathic dilated cardiomyopathy or ischaemic heart disease, challenging previous reports.
No HLA association found; leaves open genetic predisposition questions and does not support antigen testing in these conditions.
BACKGROUND: The aetiology of idiopathic dilated cardiomyopathy is believed to have an immunological component. Association with human leucocyte antigens (HLAs) has been previously reported, particularly with HLA-DR4. AIM: To determine the association of HLA type with diagnosis in a group of patients assessed for heart transplantation. METHODS: A comparison was made of frequencies of HLA types in patients with a diagnosis of idiopathic dilated cardiomyopathy or (n = 98) ischaemic heart disease (n = 170) and in controls from the North Western region (n = 857). RESULTS: Neither the patients with idiopathic dilated cardiomyopathy nor those with ischaemic heart disease showed a significant increase or decrease in any HLA frequency compared with the controls. CONCLUSION: These results suggest that there is no HLA association with idiopathic dilated cardiomyopathy or ischaemic heart disease. This conflicts with the results of some previous studies.
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Grant et al. (1994) conducted a case-control in Idiopathic dilated cardiomyopathy and ischaemic heart disease (n=1,125). Specific HLA antigens vs. Controls without the diseases was evaluated on Frequency of HLA types. Specific HLA antigens showed no significant association with idiopathic dilated cardiomyopathy or ischaemic heart disease when compared to controls.
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