Insulin Resistance versus Insulin Deficiency in Non-Insulin-Dependent Diabetes Mellitus: Problems and Prospects
Population
Patients with Non-Insulin-Dependent Diabetes Mellitus and individuals at risk
Design
Review
Authors
Discussion
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Member takes
Implication
Supports early insulin resistance monitoring in at-risk patients; leaves open optimal strategies to preserve beta-cell function.
Structured PICO
P
Population
Patients with Non-Insulin-Dependent Diabetes Mellitus (NIDDM) and individuals at risk (prediabetic, normoglycemic offspring)
This review highlights that while insulin resistance is a key early feature in the etiology of NIDDM, beta-cell dysfunction is ultimately required for the development of overt hyperglycemia.
Cite This Study
Ele Ferrannini (1998) studied this question.