Key result
Pretreatment with ATL-146e significantly reduced the total length of aspirin-induced gastric erosions in rats compared to control (3.8 mm vs 29.8 mm; P<0.01).
Why the study?
Does ATL-146e prevent aspirin-induced gastric mucosal lesions and inflammation in rats?
Population
Rats with gastric lesions induced by oral gavage of aspirin (200 mg/kg) and HCl (0.15 mol/L, 8.0 mL/kg)
Comparison
ATL-146e 2.5-5 μg/kg IP injected 30 min before… vs Control rats (aspirin/HCl without ATL-146e)
Design
Preclinical
Authors
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Should not yet influence clinical aspirin use; leaves open translation of A2A agonism to human gastroprotection.
Does ATL-146e prevent aspirin-induced gastric mucosal lesions and inflammation in rats?
Absolute Event Rate: 3.8% vs 29.8%
p-value: p=<0.01
The adenosine A2A receptor agonist ATL-146e demonstrates potent anti-ulcer and anti-inflammatory effects against aspirin-induced gastric lesions in a rat model.
Masaru Odashima (2006) studied Aspirin-induced gastric mucosal lesions. ATL-146e vs. Control was evaluated on Total length of gastric erosions (ulcer index) (p=<0.01). Pretreatment with ATL-146e significantly reduced the total length of aspirin-induced gastric erosions in rats compared to control (3.8 mm vs 29.8 mm; P<0.01).
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